Decipher Genomics · Ahmedabad, India
NGS pipelines, computational genomics, and the software underneath them.
Bioinformatics engineer based in India, currently building clinical WES/WGS and genome-assembly pipelines at Decipher Genomics & Research. Work spans four domains: clinical genomics (germline and somatic variant calling, ACMG/AMP classification), genome assembly and metagenomics (de novo bacterial and eukaryotic assembly, 16S and shotgun profiling), predictive genomics (a multi-domain polygenic risk score platform), and structural bioinformatics (molecular dynamics, protein-ligand docking).
Also builds the systems software underneath the science: vcfilt, a zero-allocation VCF filter in Go that outperforms bcftools by 12.2x, published as a bioRxiv preprint, and the ClinVar classification-history tracker powering the tools section of this site.
12.2x faster than bcftools
vcfilt, a zero-allocation VCF filter written in Go, benchmarked against bcftools 1.18 on an 18GB VCF from 1000 Genomes chromosome 20.
7,869 classification changes tracked
ClinVar Variant History, 2026. Ten monthly snapshots of the ACMG SF v3.3 panel (84 genes, 341,180 variants). Most changes reflect ClinVar’s aggregate label shifting as submissions arrive, not clinical reinterpretation.