BIOINFORMATICS
ENGINEER.
NGS pipelines, computational genomics, and the software underneath them.
NEXTFLOW DSL2·GATK4·DEEPVARIANT·CNVKIT·MANTA·PYTHON·QIIME2·DADA2·KRAKEN2·HUMANN3·SQLITE·GO·DOCKER·SINGULARITY·GROMACS·AUTODOCK VINA·STAR·DESEQ2·NEXTFLOW DSL2·GATK4·DEEPVARIANT·CNVKIT·MANTA·PYTHON·QIIME2·DADA2·KRAKEN2·HUMANN3·SQLITE·GO·DOCKER·SINGULARITY·GROMACS·AUTODOCK VINA·STAR·DESEQ2·
Performance
12.2x faster than bcftools
vcfilt, a zero-allocation VCF filter written in Go, benchmarked against bcftools 1.18 on an 18GB VCF from 1000 Genomes chromosome 20.
vcfilt (plain VCF)
147,000 var/s
bcftools (plain VCF)
12,100 var/s
vcfilt (gzip VCF)
90,600 var/s
bcftools (gzip VCF)
11,500 var/s
About
Based in India, currently building clinical WES/WGS and genome-assembly pipelines at Decipher Genomics & Research. Work spans clinical genomics, de novo assembly and metagenomics, predictive genomics, and structural bioinformatics — plus the systems software underneath it: vcfilt, a Go-based VCF filter benchmarked at 12.2x the speed of bcftools.
Selected work
Clinical Genomics
WES/WGS germline (trio-aware)
Nextflow DSL2→
ACMG/AMP classification engine
Python→
Genome Assembly & Metagenomics
De novo bacterial/yeast assembly
Nextflow DSL2→
16S rRNA amplicon profiling
QIIME2/DADA2→
Predictive Genomics
Polygenic risk score platform
43 traits, SQLite→
Software & Tools
vcfilt — VCF streaming filter (Go)
12.2x bcftools, bioRxiv→
Structural Bioinformatics
MD simulation & conformational analysis
GROMACS, PCA/clustering→